Methodology Development and Validation of Amphotericin B Stability by HPLC‑DAD
نویسندگان
چکیده
منابع مشابه
Stability of amphotericin B in infusion bottles.
Intravenous solutions of amphotericin B in 5% dextrose water with or without hydrocortisone or heparin demonstrated no appreciable loss of activity when exposed to fluorescent light for up to 24 h at 25 C (room temperature).
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Antifungal agents may differ in their fungicidal activities against Aspergillus spp. In order to compare the fungicidal activities of voriconazole and amphotericin B against 40 isolates of Aspergillus fumigatus, A. flavus, and A. terreus, we developed a new microbroth colorimetric method for assessing fungicidal activities and determining minimal fungicidal concentrations (MFCs). This methodolo...
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We have found that amphotericin B is unstable in two commonly employed fungal culture media. This instability leads to inaccuracies in determining the actual level of susceptibility of slow-growing strains that require prolonged incubation for growth. To help compensate for this problem, we have described two rapid methods of susceptibility testing.
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Unilamellar liposomal amphotericin B (AmBisome) (liposomal AMB) reduces the toxicity of this antifungal drug. The unique composition of liposomal AMB stabilizes the liposomes, producing higher sustained drug levels in plasma and reducing renal and hepatic excretion. When liposomes release their drug payload, unbound, protein-bound, and liposomal drug pools may exist simultaneously in the body. ...
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Objectives: Successful aging is an interdisciplinary concept. Despite the great body of literature on successful aging, few studies have focused on its subjective and multidimensional measurements. Thus, the present study aimed to develop an instrument to measure self-perceived successful aging. Methods: We used a mixed method approach. The successful aging dimensions were explored through an ...
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ژورنال
عنوان ژورنال: Journal of the Brazilian Chemical Society
سال: 2020
ISSN: 0103-5053
DOI: 10.21577/0103-5053.20190256